D4 Dopamine Receptor (DRD4) Locus and Attention Deficit Hyperactivity (ADHD)

The D4 dopamine receptor (DRD4) locus may be a model system for understanding the relationship between genetic variation and human cultural diversity. It has been the subject of intense interest in psychiatry, because bearers of one variant are at increased risk for attention deficit hyperactivity disorder (ADHD) (1).


1. Faraone S, Doyle A E, Mick E, Biederman J (2001) Am J Psychiatry 158:1052–1057.

-- Henry Harpending , Gregory Cochran

from "In our genes"

Quoted on Wed Jan 30th, 2013